Protection by melanin depends on its subcellular location.Although most filamentous fungi synthesize melanin via a polyketide synthase pathway, Idler Set where and how melanin biosynthesis occurs and how it is deposited as extracellular granules remain elusive.Using a forward genetic screen in the pathogen Aspergillus fumigatus, we find that mutati

A prototype for the remover of cherry tomato calyxes was designed and manufactured.The tap remover was designed and manufactured considering the conveyor transport speed, brush length and clearance, and diameter.These were adjusted in three levels to determine the optimal design factor.Performance tests were MACA conducted using Icon 513, a circula

We investigate the cosmology of mini Primordial Black Holes (PBHs) produced by large density perturbations that collapse during a stiff fluid domination phase.Such a phase can be realized by a runaway-inflaton model that crosses an inflection point or a sharp feature at the last stage of inflation.Mini Drawing Tablet PBHs evaporate promptly and reh

Centella asiatica L.extract is a promising natural agent for the treatment of atopic dermatitis.It significantly reduces inflammation due to its immunomodulatory properties, mainly attributed to the presence of pentacyclic triterpenes, namely madecassoside and asiaticoside.Their incorporation into sustainable cold-processed topical formulations, su